HCID 21073256, compound → HCID 21073470, compound

Participants

Reaction Steps

2-Benzyloxy-7-{2-[4-(2,3-dichloro-phenyl)-piperazin-1-yl]-ethoxy}-[1,8]naphthyridine (1.30 g, 2.55 mmol) was hydrogenated using 5% Pd/C (0.4 g) in MeOH (100 mL) for 40 min. The reaction was filtered and concentrated. Purification by liquid chromatography (2–3% MeOH/EtOAc with 1% NH4OH) gave the title compound as a white foam (600 mg, 1.43 mmol, 56%). The HCl salt was prepared using 1 N HCl in Et2O to give a white solid. MS: APCI: M+1: 419.1 (Exact Mass: 418.10).

Provenance & Evidence