Triethylamine → HCID 21073531, compound

Participants

Reaction Steps

To a solution of 4-methyl-4-(7-oxo-5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yloxy)-pentanal (335 mg, crude) in DCE (6 mL) was added 2,3-dichlorophenyl-piperazine hydrochloride (335 mg, 1.25 mmol) followed by Et3N (0.35 mL, 2.50 mmol). The mixture was stirred for 10 min and then powdered NaBH(OAc)3 (365 mg, 1.72 mmol) was added. The reaction was stirred at room temperature for 2 h and then quenched with saturated NaHCO3. The mixture was extracted with EtOAc (2×). The organic layer was washed with saturated NaHCO3, H2O and brine, dried over Na2SO4 and concentrated. Purification by liquid chromatography (4% MeOH/CH2Cl2) gave the title compound as a white foam (395 mg, 0.827 mmol, 67% over 2 steps). The foam was dissolved in Et2O and 1 N HCl in Et2O (0.85 mL) was added. The resulting white precipitate was collected by filtration, washed with Et2O and dried to give a white solid (386 mg). MS: APCI: M+1: 477.1 (Exact Mass: 476.17).

Provenance & Evidence