HCID 69417640, compound → HCID 21073879, compound

Participants

Reaction Steps

7-{5-[4-(2-Chloro-3-methyl-phenyl)-piperazin-1-yl]-pent-1-enyl}-3,4-dihydro-1H-[1,8]naphthyridin-2-one (0.322 g, 0.758 mmol) was hydrogenated using Ra—Ni (0.5 g) in 1:1 EtOH/THF (50 mL) for 21 h. The reaction was filtered and concentrated. Purification by liquid chromatography (SiO2, 5% MeOH/CH2Cl2 to 7% MeOH/CH2Cl2) gave the title compound as a light yellow foam (282 mg, 0.660 mmol, 87%). MS: APCI: M+1: 427.3 (Exact Mass: 426.22).

Provenance & Evidence