Diethyl Ether → HCID 21073883, compound

Participants

Reaction Steps

7-{5-[4-(2-Chloro-4-fluoro-phenyl)-piperazin-1-yl]-pent-1-enyl}-3,4-dihydro-1H-[1,8]naphthyridin-2-one (0.268 g, 0.623 mmol) was hydrogenated using Ra—Ni (0.2 g) in THF for 13 hours. The reaction was filtered and concentrated to give an oil. Et2O was added and the product crashed out. The mixture was filtered and dried to give the title compound as a white solid (0.214 g, 80%). MS: APCI: M+1: 431.3 (Exact Mass: 430.19).

Provenance & Evidence