HCID 69421276, compound → HCID 21073893, compound

Participants

Reaction Steps

7-{5-[4-(6-Methyl-pyridin-2-yl)-piperazin-1-yl]-pent-1-enyl}-3,4-dihydro-1H-[1,8]naphthyridin-2-one (0.343 g, 0.876 mmol) was hydrogenated using 20% Pd/C in EtOH for 103 h. The reaction was filtered and concentrated. Purification by liquid chromatography (Biotage 12 SiO2 column, CH2Cl2 to 1% MeOH/CH2Cl2) followed by recrystallization from Et2O gave the title compound as a white powder (42 mg, 0.01 mmol, 12%). MS: APCI: M+1: 394.2 (Exact Mass: 393.25).

Provenance & Evidence