HCID 69422316, compound → HCID 21073891, compound

Participants

Reaction Steps

7-{5-[4-(6-Ethyl-pyridin-2-yl)-piperazin-1-yl]-pent-1-enyl}-3,4-dihydro-1H-[1,8]naphthyridin-2-one (0.515 g, 1.27 mmol) was hydrogenated using 20% Pd/C in EtOH for 103 h. The reaction was filtered and concentrated. Purification by liquid chromatography (Biotage 12 SiO2 column, CH2Cl2 to 1% MeOH/CH2Cl2) followed by recrystallization from Et2O gave the title compound as a solid (50 mg, 0.012 mmol, 10%). MS: APCI: M+1: 408.2 (Exact Mass: 407.27).

Provenance & Evidence