HuagongsheHuagongshe Chemistry Print Report · For research reference only
7-{5-[4-(6-Cyclopropyl-pyridin-2-yl)-piperazin-1-yl]-pent-1-enyl}-3,4-dihydro-1H-[1,8]naphthyridin-2-one → 7-{5-[4-(6-Cyclopropyl-pyridin-2-yl)-piperazin-1-yl]-pentyl}-3,4-dihydro-1H-[1,8]naphthyridin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7-{5-[4-(6-Cyclopropyl-pyridin-2-yl)-piperazin-1-yl]-pent-1-enyl}-3,4-dihydro-1H-[1,8]naphthyridin-2-one | HCID 69422398 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 7-{5-[4-(6-Cyclopropyl-pyridin-2-yl)-piperazin-1-yl]-pentyl}-3,4-dihydro-1H-[1,8]naphthyridin-2-one | HCID 21073889 | 83% |
Reaction Steps
7-{5-[4-(6-Cyclopropyl-pyridin-2-yl)-piperazin-1-yl]-pent-1-enyl}-3,4-dihydro-1H-[1,8]naphthyridin-2-one (0.347 g, 0.831 mmol) was hydrogenated using 20% Pd/C in THF for 15 h. The reaction was filtered and concentrated. Recrystallization from hot CH3CN gave the title compound as a white powder (288 mg, 0.686 mmol, 83%). MS: APCI: M+1: 420.3 (Exact Mass: 419.27).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07160888B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-f9d522eb69204a01a636e3f8a711c3d6 |
| Source note | uspto-grants-2007_01 |