HCID 69417514, compound → HCID 21073885, compound

Participants

Reaction Steps

7-{5-[4-(4,6-Dimethyl-pyridin-2-yl)-piperazin-1-yl]-pent-1-enyl}-3,4-dihydro-1H-[1,8]naphthyridin-2-one (0.54 g, 1.33 mmol) was hydrogenated using 20% Pd/C in EtOH for 58 h. The reaction was filtered and concentrated. Purification by liquid chromatography (Biotage 12 SiO2 column, CHCl3 to 1% MeOH/CHCl3) followed by recrystallization from Et2O/hexanes gave the title compound as an off-white solid (313 mg, 0.761 mmol, 57%). MS: APCI: M+1: 408.2 (Exact Mass: 407.27).

Provenance & Evidence