HCID 69420265, compound → HCID 21073869, compound

Participants

Reaction Steps

7-{5-[4-(2,3-Dichloro-phenyl)-piperazin-1-yl]-pent-1-enyl}-1H-[1,8]naphthyridin-2-one (160 mg, 0.361 mmol) was hydrogenated using Raney Nickel (0.2 g) in MeOH for 42 h. The reaction was filtered and concentrated. Purification by liquid chromatography (5% MeOH/CH2Cl2 with 1% NH4OH) gave the title compound as a white foam (109 mg, 0.245 mmol, 68%), which was further purified by HPLC to remove a small amount of over-reduced side-product. MS: APCI: M−1: 443.1 (Exact Mass: 444.15).

Provenance & Evidence