HCID 69419265, compound → HCID 21073870, compound

Participants

Reaction Steps

A Parr shaker was charged with PtO2 (0.12 g) and EtOAc (25 mL) was added under N2. The catalyst was shaken under a H2 atmosphere (50 psi) for 10 min and a suspension of 7-{5-[4-(2,3-dichloro-phenyl)-piperazin-1-yl]-pent-1-enyl}-3,3-dimethyl-3,4-dihydro-1H-[1,8]naphthyridin-2-one (0.54 g, 1.15 mmol) in EtOAc (125 mL) was added. The mixture was shaken under H2 (50 psi) for 1.5 h. The reaction was filtered through Celite washing with MeOH and the filtrate was concentrated to give an oily residue. Hexanes was added and the mixture was concentrated to give the title compound as a white solid (0.54 g, 99%). MS: ESI: m/z: 475.32 (Exact Mass: 474.20).

Provenance & Evidence