Sodium borohydride → HCID 21073544, compound

Participants

Reaction Steps

To a solution of 7-{4-[4-(2,3-dichloro-phenyl)-piperazin-1-yl]-butoxy}-3,3-dimethyl-1H-[1,8]naphthyridine-2,4-dione (0.132 g, 0.268 mmol) in THF (2 mL), cooled to 0° C. was added NaBH4 (0.013 g, 0.335 mmol). The reaction was warmed to room temperature and stirred for 3 hours. The reaction was quenched with saturated NaHCO3 and partitioned between EtOAc and water. The organic layer was washed with brine, dried over Na2SO4 and concentrated to give the title compound as a white solid (0.095 g, 0.192 mmol, 57%). MS: APCI: M+1: 493.1 (Exact Mass: 492.17).

Provenance & Evidence