HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2,3-Dihydro-1H-inden-4-yl)piperazine → 6-Fluoro-7-[4-(4-indan-4-yl-piperazin-1-yl)-butoxy]-3,4-dihydro-1H-[1,8]naphthyridin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2,3-Dihydro-1H-inden-4-yl)piperazine | HCID 18474829 | — |
| Reactant | 4-(3-Fluoro-7-oxo-5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yloxy)-butyraldehyde | HCID 21073340 | — |
| Product | 6-Fluoro-7-[4-(4-indan-4-yl-piperazin-1-yl)-butoxy]-3,4-dihydro-1H-[1,8]naphthyridin-2-one | HCID 21073463 | — |
Reaction Steps
The title compound was prepared by reductive amination of 4-(3-fluoro-7-oxo-5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yloxy)-butyraldehyde with 1-indan-4-yl-piperazine according to the above procedure. MS: APCI: M+1: 439.2 (Exact Mass: 438.24).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07160888B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-1f08cea9cf684dbe91f14f05ab260662 |
| Source note | uspto-grants-2007_01 |