HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(1-Naphthyl)piperazine hydrochloride → 5-Methyl-7-[4-(4-naphthalen-1-yl-piperazin-1-yl)-butoxy]-3,4-dihydro-1H-[1,8]naphthyridin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(1-Naphthyl)piperazine hydrochloride | HCID 2737391 | — |
| Reactant | 4-(4-Methyl-7-oxo-5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yloxy)-butyraldehyde | HCID 21073350 | — |
| Product | 5-Methyl-7-[4-(4-naphthalen-1-yl-piperazin-1-yl)-butoxy]-3,4-dihydro-1H-[1,8]naphthyridin-2-one | HCID 11561349 | — |
Reaction Steps
The title compound was prepared by reductive amination of 4-(4-methyl-7-oxo-5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yloxy)-butyraldehyde with 1-naphthalen-1-yl-piperazine hydrochloride according to the above procedure. MS: APCI: M+1: 445.2 (Exact Mass: 444.25).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07160888B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-a07e62e5da584a0a9e58a2ccd096d1b6 |
| Source note | uspto-grants-2007_01 |