HCID 69419982, compound → HCID 21073447, compound

Participants

Reaction Steps

6-{5-[4-(5,6,7,8-Tetrahydro-naphthalen-1-yl)-piperazin-1-yl]-pent-1-enyl}-4H-pyrido[3,2-b][1,4]oxazin-3-one (0.098 g, 0.226 mmol) was hydrogenated using Ra—Ni in THF for 16 hours. The reaction was filtered and concentrated to give an oil. Purification by chromatography on silica gel (0–5% MeOH/EtOAc) afforded the title compound as a film (0.059 g, 61%). This was dissolved in Et2O and 1M HCl in Et2O (1 equivalent) was added. The resulting precipitate was filtered and dried to give a white solid. MS: APCI: M+1: 435.5 (Exact Mass: 434.27).

Provenance & Evidence