4-(4-Naphthalen-1-yl-piperazin-1-yl)-butan-1-ol → 6-Fluoro-4-methyl-2-[4-(4-naphthalen-1-yl-piperazin-1-yl)-butoxy]-8H-pyrido[2,3-d]pyrimidin-7-one

HRID 1373626Notes

Reaction equation

HRID 1373626 reaction equation
[F:1][C:2]1[C:16](=[O:17])[NH:15][C:5]2[N:6]=[C:7](S(C)(=O)=O)[N:8]=[C:9]([CH3:10])[C:4]=2[CH:3]=1.[C:18]1([N:28]2[CH2:33][CH2:32][N:31]([CH2:34][CH2:35][CH2:36][CH2:37][OH:38])[CH2:30][CH2:29]2)[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH:21]=[CH:20][CH:19]=1>>[F:1][C:2]1[C:16](=[O:17])[NH:15][C:5]2[N:6]=[C:7]([O:38][CH2:37][CH2:36][CH2:35][CH2:34][N:31]3[CH2:32][CH2:33][N:28]([C:18]4[C:27]5[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=5)[CH:21]=[CH:20][CH:19]=4)[CH2:29][CH2:30]3)[N:8]=[C:9]([CH3:10])[C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 210733524-(4-Naphthalen-1-yl-piperazin-1-yl)-butan-1-olHCID 210734566-fluoro-2-methanesulfonyl-4-methyl-8H-pyrido[2,3-d]pyrimidin-7-one

Product 1

HCID 210734586-Fluoro-4-methyl-2-[4-(4-naphthalen-1-yl-piperazin-1-yl)-butoxy]-8H-pyrido[2,3-d]pyrimidin-7-one

Procedure

Following the same procedure as in Example H12 and starting from 6-fluoro-2-methanesulfonyl-4-methyl-8H-pyrido[2,3-d]pyrimidin-7-one (300 mg, 1.166 mmol, U.S. Pat. No. 6,498,163) and 4-(4-naphthalen-1-yl-piperazin-1-yl)-butan-1-ol (331 mg, 1.166 mmol), the title compound was made as a solid (323 mg, 0.684 mmol, 58.7%). MS: APCI: M+1: 462.1 (Exact Mass: 461.22).

Sources & evidence

ORD record
ord-90b025a1209e442caf93835f607448bd
Source dataset
uspto-grants-2007_01
Patent number
US07160888B2

Reaction notes

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