HCID 69419793, compound → HCID 21073876, compound

Participants

Reaction Steps

7-{5-[4-(2,3-Dichloro-phenyl)-piperazin-1-yl]-pent-1-enyl}-4,4-dimethyl-1,4-dihydro-pyrido[4,3-d][1,3]oxazin-2-one (452 mg, 0.95 mmol) was hydrogentated using Ra—Ni in EtOH/THF. The reaction was filtered and concentrated. Purification by liquid chromatography (5% MeOH/CH2Cl2 with 0.5% NH4OH) gave a white foam (385 mg, 85% pure). The foam was dissolved in a minimal amount of EtOAc and, upon standing, a white precipitate formed. The precipitate was filtered and washed with Et2O to give the title compound as a white solid (200 mg, 0.42 mmol, 44%). MS: APCI: M+1: 477.1 (Exact Mass: 476.17).

Provenance & Evidence