Piperazine → HCID 21073348, compound

Participants

Reaction Steps

The aldehyde (0.3 mmol) and the piperazine (60.306 mmol) were combined in methylene chloride and stirred in a vial over sieves for 10 min. Sodium triacetoxyborohydride (0.42 mmol) was added and the reaction was stirred overnight. The reaction was quenched by slowly adding water and then the mixture was filtered. The residue was partitioned between CH2Cl2 and water and the organic layer was concentrated. Purification by liquid chromatography (MPLC, gradient of 100% CH2Cl2 to 100% of a 10% MeOH in CH2Cl2 solution) gave the title compound. The final products were made into hydrochloride salts by treatment with a solution of saturated HCl in MeOH.

Provenance & Evidence