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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1373655Generated: October 26, 2026

8-(1-piperazinyl)Quinoline → 6-Fluoro-7-[4-(4-quinolin-8-yl-piperazin-1-yl)-butoxy]-3,4-dihydro-1H-[1,8]naphthyridin-2-one

https://huagongshe.com/reaction/1373655

Reaction equation

Participants

RoleNameHCIDCharge
Reactant8-(1-piperazinyl)QuinolineHCID 11830786—
Reactant4-(3-Fluoro-7-oxo-5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yloxy)-butyraldehydeHCID 21073340—
Product6-Fluoro-7-[4-(4-quinolin-8-yl-piperazin-1-yl)-butoxy]-3,4-dihydro-1H-[1,8]naphthyridin-2-oneHCID 21073465—

Reaction Steps

The title compound was prepared by reductive amination of 4-(3-fluoro-7-oxo-5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yloxy)-butyraldehyde with 8-piperazin-1-yl-quinoline using a procedure similar to Example A1′. MS: APCI: M+1: 450.2 (Exact Mass: 449.22).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07160888B2
Source datasetuspto-grants-2007_01
ORD IDord-e9085fb703444eddb683f7dfbb969fe0
Source noteuspto-grants-2007_01