5-(Piperazin-1-yl)isoquinoline → HCID 21073464, compound

HRID 1373656Notes

Reaction equation

HRID 1373656 reaction equation
[F:1][C:2]1[C:3]([O:13][CH2:14][CH2:15][CH2:16][CH:17]=O)=[N:4][C:5]2[NH:6][C:7](=[O:12])[CH2:8][CH2:9][C:10]=2[CH:11]=1.[N:19]1([C:25]2[CH:34]=[CH:33][CH:32]=[C:31]3[C:26]=2[CH:27]=[CH:28][N:29]=[CH:30]3)[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>>[F:1][C:2]1[CH:11]=[C:10]2[C:5](=[N:4][C:3]=1[O:13][CH2:14][CH2:15][CH2:16][CH2:17][N:22]1[CH2:23][CH2:24][N:19]([C:25]3[CH:34]=[CH:33][CH:32]=[C:31]4[C:26]=3[CH:27]=[CH:28][N:29]=[CH:30]4)[CH2:20][CH2:21]1)[NH:6][C:7](=[O:12])[CH2:8][CH2:9]2

Participants

3

Reactant 2

HCID 184141255-(Piperazin-1-yl)isoquinolineHCID 210733404-(3-Fluoro-7-oxo-5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yloxy)-butyraldehyde

Product 1

HCID 21073464HCID 21073464, compound

Procedure

The title compound was prepared by reductive amination of 4-(3-fluoro-7-oxo-5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yloxy)-butyraldehyde with 5-piperazin-1-yl-isoquinoline using a procedure similar to Example A1′. MS: APCI: M+1: 450.2 (Exact Mass: 449.22).

Sources & evidence

ORD record
ord-4978e55a3d414d2ea5006bc4b06ba5ba
Source dataset
uspto-grants-2007_01
Patent number
US07160888B2

Reaction notes

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