Gamma-Aminobutyric Acid → HCID 178454267, compound

Participants

Reaction Conditions

Reaction Steps

4-Aminobutyric acid (100 mg, 0.97 mmol) was dissolved in tetrahydrofuran (0.3 mL) and water (0.03 mL), combined with 1,3-bis(tert-butoxycarbonyl)-2-methyl-2-thiopseudourea (340 mg, 1.2 mmol) and stirred at 60° C. overnight. The reaction solution was concentrated under reduced pressure, and the residue was subjected to a column chromatography to obtain 4-(2,3-di-tert-butoxycarbonylguanidino)butyric acid (compound 8; yield: 181 mg).

Provenance & Evidence