Ammonia → HCID 58781869, compound

Participants

Reaction Steps

Methanol saturated with ammonia (20 mL) at 0° C. was added to a mixture of (5S,2R,3R)-2-{6-[(4-hydroxycyclohexyl)amino]purin-9-yl}-5-(benzoyloxymethyl)oxolan-3-yl acetate and (5S,2R,3R)-2-{6-[(4-hydroxycyclohexyl)amino]purin-9-yl}-5-(benzoyloxymethyl)oxolan-3-ol. The mixture was stirred at room temperature for 36 hours. The solvent was evaporated under reduced pressure, and the residue was purified on a Chromatotron to obtain (5S,2R,3R)-2-{6-[(4-hydroxycyclohexyl)amino]purin-9-yl}-5-(hydroxymethyl)oxolan-3-ol, a compound of Formula I.

Provenance & Evidence