反应详情

温度

0 °C

To a stirring cold (0° C.) solution of POBr3 (0.6 mol, 171 g) in CH2Cl2 (1.6 L) was added dropwise DMF (0.75 L) over a period of 1 h. A solution of 2-bromo-4-hydroxymethyl-benzaldehyde (0.49 mol, 107 g) in CH2Cl2 (0.75 L) was then added dropwise over a period of 0.5 h. The resulting mixture was stirred at 0° C. for another 0.5 h and was then transferred via a cannula to a cold (0° C.) stirring aqueous solution of NaHCO3 (3 L, 1M) while maintaining the temperature of the aqueous solution below 10° C. After the transfer was completed, the mixture was extracted with CH2Cl2 (2 L). The organic extract was separated and washed with H2O (3 L) and brine (3 L), dried with MgSO4 (anhyd.) and concentrated to give an oil . The residue was extracted with 10% EtOAc/hexane (2 L). The organic extract was washed with H2O (2×1 L), dried with MgSO4 (anhyd.) and concentrated to a solid which was swished with hexane to give 154 g (˜100%) of the title compound as a beige solid.

1. customwas then transferred via a cannula to a cold (0° C.)
2. temperaturewhile maintaining the temperature of the aqueous solution below 10° C
3. extractionthe mixture was extracted with CH2Cl2 (2 L)
4. extractionThe organic extract
5. customwas separated
6. washwashed with H2O (3 L) and brine (3 L)
7. dry with materialdried with MgSO4 (anhyd.)
8. concentrationconcentrated
9. customto give an oil
10. extractionThe residue was extracted with 10% EtOAc/hexane (2 L)
11. extractionThe organic extract
12. washwas washed with H2O (2×1 L)
13. dry with materialdried with MgSO4 (anhyd.)
14. concentrationconcentrated to a solid which