反应详情

A mixture of 2-chloro-N-(5-chloropyridin-2-yl)pyridine-3-carboxamide (1.00 g, 3.7 mmol) and 4-(4-methylhexahydro-1,4-diazepin-1-yl)benzylamine (0.63 g, 2.9 mmol), in 5 mL of DMSO, was heated in a sealed tube at 70–75° C. for 35 h. This reaction mixture was diluted with 250 mL of water, basified with 2 N NaOH, and extracted with ethyl acetate and evaporated to give 0.83 g crude product. Flash chromatography purification with 10% MeOH—CHCl3, 1% NH4OH gave the title product (0.11 g, 8.5%).

1. extractionextracted with ethyl acetate
2. customevaporated
3. customto give 0.83 g crude product
4. customFlash chromatography purification with 10% MeOH—CHCl3, 1% NH4OH