1-Methylhomopiperazine → HCID 10302388, compound

HRID 1373704Notes

Reaction equation

[F:1][C:2]1[CH:3]=[CH:4][C:5]([NH:18][C:19](=[O:31])[C:20]2[CH:25]=[CH:24][C:23](F)=[CH:22][C:21]=2[O:27][CH:28]([CH3:30])[CH3:29])=[C:6]([CH:17]=1)[C:7]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][N:11]=1)=[O:8].[CH3:32][N:33]1[CH2:39][CH2:38][CH2:37][NH:36][CH2:35][CH2:34]1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([NH:18][C:19](=[O:31])[C:20]2[CH:25]=[CH:24][C:23]([N:36]3[CH2:37][CH2:38][CH2:39][N:33]([CH3:32])[CH2:34][CH2:35]3)=[CH:22][C:21]=2[O:27][CH:28]([CH3:30])[CH3:29])=[C:6]([CH:17]=1)[C:7]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][N:11]=1)=[O:8]

Participants

Reactant 2

HCID 2283491-Methylhomopiperazine

HCID 21075347HCID 21075347, compound

Product 1

HCID 10302388HCID 10302388, compoundYield 99.9%

Procedure

Prepared from 5-fluoro-2-(4-fluoro-2-isopropoxybenzoylamino)-N-(5-chloropyridin-2-yl)benzamide (159 mg, 0.356 mmol) and 1-methyl-hexahydro-1,4-diazepine (203 mg, 1.77 mmol, 5 eq) to provide 192 mg (82%) of the title compound.

Sources & evidence

ORD record: ord-fec9b3a965ab4e548b16bb5bc52b6924
Source dataset: uspto-grants-2007_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07163938B2

Reaction notes

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