Hydrochloric Acid → Methyl D-2-(4-fluorophenyl)glycinate

Participants

Reaction Steps

(R)-Amino-(4-fluoro-phenyl)-acetic acid was treated with HCl gas (8 g) dissolved in methanol at room temperature for 24 hours. The reaction mixture was concentrated and aqueous sodium bicarbonate was added until the pH of the mixture remained basic. The aqueous layer was extracted three times with dichloromethane. The combined extracts were dried (Na2SO4) and concentrated afford the title compound as an oil. 1HNMR (400 MHz, CDCl3)δ 1.90 (br s, 2H), 3.67 (s, 3H), 4.58 (s, 1H), 7.00 (m, 2H), 7.30 (m, 2H).

Provenance & Evidence