4-Chlorobenzenesulfonyl chloride → HCID 69317190, compound

HRID 1373740Notes

Reaction equation

HRID 1373740 reaction equation
[NH2:1][C@H:2]([C:6]1[CH:11]=[CH:10][C:9]([F:12])=[CH:8][CH:7]=1)[C:3]([NH2:5])=[O:4].[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([S:20](Cl)(=[O:22])=[O:21])=[CH:16][CH:15]=1>>[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([S:20]([NH:1][C@H:2]([C:6]2[CH:11]=[CH:10][C:9]([F:12])=[CH:8][CH:7]=2)[C:3]([NH2:5])=[O:4])(=[O:22])=[O:21])=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 73984-Chlorobenzenesulfonyl chlorideHCID 69316599(αR)-α-Amino-4-fluorobenzeneacetamide

Product 1

HCID 69317190HCID 69317190, compound

Procedure

The title compound was synthesized according to the procedure of Preparation 3 employing (R)-2-amino-2-(4-fluoro-phenyl)-acetamide and 4-chlorobenzenesulfonylchloride to afford the desired product. 1HNMR (400 MHz, CD3OD)δ 4.87 (s, 1H), 6.94 (m, 2H), 7.24 m, 2H), 7.6 (dd, 4H, J=2.1, 103).

Workup

  1. customThe title compound was synthesized

Sources & evidence

ORD record
ord-3ad1b4acff324aa7a61f5877e415731e
Source dataset
uspto-grants-2007_01
Patent number
US07163942B2

Reaction notes

Loading…