2-Fluoropyridine-4-boronic acid → HCID 17953061, compound

Participants

Reaction Steps

In a similar manner to that in Example 28, from 3-bromo-N-cyclopentyl-2-(4-fluorophenyl)pyrazolo[1,5-α]pyridin-7-amine (240 mg, 0.64 mmol) and 2-fluoropyridin-4-ylboronic acid (271 mg, 1.92 mmol) after heating to 100° C. for 1.5 hours was formed N-cyclopentyl-2-(4-fluorophenyl)-3-(2-fluoro-4-pyridinyl)pyrazolo[1,5-α]pyridin-7-amine (180 mg, 72%) as a greenish solid. 1H NMR (CDCl3): δ 8.12 (d, 1H), 7.56 (m, 2H), 7.27 (m, 1H), 7.13–7.02 (m, 4H), 6.90 (s, 1H), 6.05–6.01 (m, 2H), 4.02 (m, 1H), 2.16 (m, 2H), 1.86–1.68 (m, 6H); 19F NMR (CDCl3) δ −68.65, −113.06; MS m/z 391 (M+1).

Provenance & Evidence