Hydrazine → HCID 10135743, compound

Participants

Reaction Steps

In a similar manner as described in Example 29, from N-cyclopentyl-2-(4-fluorophenyl)-3-(2-fluoro-4-pyridinyl)pyrazolo[1,5-α]pyridin-7-amine (45 mg, 0.12 mmol) and anhydrous hydrazine (0.5 mL) in ethanol (4 mL) at 100° C. for 13 hours was formed N-cyclopentyl-2-(4-fluorophenyl)-3-(2-hydrazino-4-pyridinyl)pyrazolo[1,5-α]pyridin-7-amine (30 mg, 65%) as a solid. 1H NMR (CDCl3): δ 8.05 (d, 1H), 7.61 (m, 2H), 7.20 (t, 1H), 7.09–6.99 (m, 4H), 6.71 (s, 1H), 6.63 (d, 1H), 6.03–5.96 (m, 3H), 4.01 (broad m, 2H), 2.14 (m, 2H), 1.84–1.68 (m, 6H); 19F NMR (CDCl3) δ −113.66; MS m/z 403 (M+1).

Provenance & Evidence