Pyridinium, 1-amino-, iodide (1:1) → HCID 21948674, compound

HRID 1373826Notes

Reaction equation

HRID 1373826 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]#[C:9][C:10]([O:12][CH3:13])=[O:11])=[CH:4][CH:3]=1.[I-].[NH2:15][N+:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.N1(C2CCCCCCCCCC2)CCCN=CCCCCC1>C(#N)C>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:9]([C:10]([O:12][CH3:13])=[O:11])=[C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][N:16]3[N:15]=2)=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 2733704Pyridinium, 1-amino-, iodide (1:1)HCID 111268212-Propynoic acid, 3-(4-fluorophenyl)-, methyl esterHCID 1296629601,8-Diazabicycloundec-7ene

Product 1

HCID 21948674HCID 21948674, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent2×

Procedure

A stirred solution of methyl 3-(4-fluorophenyl)propiolate (8.02 g, 45 mmol) and 1-aminopyridinium iodide (10 g, 45 mmol) in dry acetonitrile (150 mL) was cooled to about 0° C. A solution of 1,8-diazabicycloundec-7-ene (13.7 g, 90 mmol) in dry acetonitrile (50 mL) was added dropwise over 1 hour. The mixture was allowed to stir at room temperature for about 18 h. The reaction mixture was cooled in an ice bath for about 30 min and the precipitate was collected by filtration and washed with cold acetonitrile (10 mL). The solid was dried under reduced pressure to give the title compound as a white solid, 8.48 g (70%). 1H NMR (CDCl3) δ 8.50 (d, 1H, J=8.4 Hz), 8.18 (d, 1H, J=8.8 Hz), 7.78 (m, 2H), 7.42 (t, 1H, J=8.4 Hz), 7.13 (t, 2H, J=8.8 Hz), 6.97 (td, 1H, J=6.8, 1 Hz). ). MS (+ve ion electrospray) 271 (100), (MH+).

Workup

  1. temperatureThe reaction mixture was cooled in an ice bath for about 30 min
  2. filtrationthe precipitate was collected by filtration
  3. washwashed with cold acetonitrile (10 mL)
  4. customThe solid was dried under reduced pressure

Sources & evidence

ORD record
ord-03f71c5cd5414bfbaf629377df907bff
Source dataset
uspto-grants-2007_01
Patent number
US07163940B2

Reaction notes

Loading…