反应详情

温度

120 °C

A mixture of 7-chloro-2-(4-fluorophenyl)-3-(4-pyridinyl)pyrazolo[1,5-α]pyridine (100 mg) and imidazole (5 eq.) in dimethylsulfoxide (2 mL) in sealed tube was heated at 120° C. overnight. The mixture was evaporated to dryness and purified by preparative thin layer chromatography to give 2-(4-fluorophenyl)-7-(1H-imidazol-1-yl)-3-pyridin-4-ylpyrazolo[1,5-α]pyridine. 1H NMR (CDCl3): δ 8.65 (d, 2H, J=5,6 Hz), 7.96 (s, 1H), 7.60 (d, 1H, J=9.5 Hz), 7.44–7.47 (m, 2H), 7.34–7.38 (m, 4H), 7.28 (d, 2H, J=5.7 Hz), 7.02 (m, 2H); MS m/z 356 (M+1).

1. customThe mixture was evaporated to dryness
2. custompurified by preparative thin layer chromatography