2-Fluoropyridine-4-boronic acid → HCID 10157930, compound

Participants

Reaction Steps

In a similar manner to that in Example 28, from 3-bromo-7-chloro-2-(4-fluorophenyl)pyrazolo[1,5-α]pyridine (305 mg, 0.94 mmol) and 2-fluoropyridin-4-ylboronic acid (182 mg, 1.30 mmol) after heating to 100° C. for 1.5 hours was formed 2-(4-fluorophenyl)-3,7-bis(2-fluoropyridin-4-yl)pyrazolo[1,5-α]pyridine (90 mg, 24%). 1H NMR (CDCl3): δ 8.47 (d, 1H), 8.29 (d 1H), 7.89 (br d, 1H), 7.78 (d, 1H), 7.72 (s, 1H), 7.58 (dd, 2H), 7.44 (dd, 1H), 7.20 (br d, 1H), 7.15 (d, 1H), 7.13 (t, 2H), 7.05 (s, 1H); MS m/z 403 (M+1).

Provenance & Evidence