Sodium borohydride → HCID 21075801, compound

Participants

Reaction Steps

A solution of N-benzylidene(2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)amine (575 mg, 1.75 mmol) in 40 mL of MeOH was treated with NaBH4 (250 mg, 6.58 mmol). After stirring for 4 h, the reaction was quenched with saturated NaHCO3 solution and extracted into CHCl3. The organic portion was washed with H2O and brine and dried over Na2SO4. Chromatography (SiO2, 50–67% EtOAc/hexanes) gave N-benzyl(2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)amine (427 mg) as a yellow solid.

Provenance & Evidence