反应详情

A solution of N-(2-ethoxymethyl-1H-imidazo[4,5-c]quinolin-1-yl)(furan-2-ylmethylene)amine (1.86 g, 5.81 mmol) in 20 mL of methanol was treated with NaBH4 (0.659 g, 17.4 mmol) and stirred under an atmosphere of nitrogen. After 18 h the reaction was quenched by addition of 20 mL of water. The reaction mixture was concentrated under reduced pressure and dissolved in CHCl3. The organic portion was washed with 2% Na2CO3 solution, water and brine, dried over Na2SO4, filtered and concentrated under reduced pressure to yield N-(2-ethoxymethyl-1H-imidazo[4,5-c]quinolin-1-yl)(furan-2-ylmethyl)amine (1.70 g) as a thick orange syrup.

1. customAfter 18 h the reaction was quenched by addition of 20 mL of water
2. concentrationThe reaction mixture was concentrated under reduced pressure
3. dissolutiondissolved in CHCl3
4. washThe organic portion was washed with 2% Na2CO3 solution, water and brine
5. dry with materialdried over Na2SO4
6. filtrationfiltered
7. concentrationconcentrated under reduced pressure