N-(morpholin-4-yl)(3-nitroquinolin-4-yl)amine → HCID 21075796, compound

Participants

Reaction Steps

A solution of N-(morpholin-4-yl)(3-nitroquinolin4-yl)amine (4.54 g, 16.6 mmol) in 150 mL of toluene was treated with 5% platinum on carbon (0.65 g, 0.17 mmol) and the mixture was shaken under an atmosphere of hydrogen (3.8×105 Pa). After 15 h, the reaction mixture was filtered through a pad of CELITE filter agent and rinsed with 4:1 toluene:MeOH. The filtrate was concentrated under reduced pressure to yield N4-(morpholin-4-yl)quinoline-3,4-diamine (4.06 g) as a red foam.

Provenance & Evidence