HCID 12094927, compound → HCID 12094928, compound
Reaction equation
[C:1]1([C:6]2[CH:7]=[C:8]([CH2:12][OH:13])[CH:9]=[CH:10][CH:11]=2)[CH2:5][CH2:4][CH2:3][CH:2]=1>O=[Mn]=O.C(Cl)(Cl)Cl>[C:1]1([C:6]2[CH:7]=[C:8]([CH:9]=[CH:10][CH:11]=2)[CH:12]=[O:13])[CH2:5][CH2:4][CH2:3][CH:2]=1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Conditions
- Temperature
- 60 °C
Procedure
1.35 g (8 mmol) of (3-cyclopenten-1-ylphenyl)methanol (5a) and 80 ml of chloroform are introduced into a round-bottomed flask. 6.8 g of MnO2 are then added and the suspension is heated at 60° C. for 2 hours. The mixture is filtered in the hot state, the precipitate washed with chloroform and then the filtrate concentrated under reduced pressure. The title product (1.05 g) is obtained in the form of a yellow oil which is used in the next step without further purification.
Workup
- filtrationThe mixture is filtered in the hot state
- washthe precipitate washed with chloroform
- concentrationthe filtrate concentrated under reduced pressure
Sources & evidence
- ORD record
- ord-91e66b52a2694e669d576b4da976f71f
- Source dataset
- uspto-grants-2007_01
- Patent number
- US07163957B2
Reaction notes
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