Water → 4-(4-Cyanophenyl)butyl methanesulfonate

Participants

Reaction Steps

Methanesulfonyl chloride (2.32 mL, 30 mmol) was added to a cooled is (0° C.), stirred solution of 4-(4-hydroxybutyl)benzonitrile (from step (ii) above, 5.2 g, 29.7 mmol) and triethylamine (4.35 mL) in dichloromethane (50 mL). The resulting mixture was stirred for 4 h before water (150 mL) was added, and the organic layer separated, dried and concentrated to give the sub-title compound. This product was used directly in the next step without further purification.

Provenance & Evidence