HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2-Hydroxyethyl)piperazine → 1-Acetyl-4-(2-hydroxyethyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2-Hydroxyethyl)piperazine | HCID 7677 | — |
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-Acetyl-4-(2-hydroxyethyl)piperazine | HCID 4739629 | 65% |
Reaction Steps
A solution of 2-(1-piperazinyl)-l-ethanol (6.5 g, 0.05 mol) in DCM (5 mL) was treated with acetic acid anhydride (5.1 g, 0.05 mol), added dropwise. During addition, the reaction temperature rose from 22 to 60° C. The reaction mixture was evaporated several times with toluene to yield 5.6 g (65%) of the sub-title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07164017B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-f3ea944e53944cc3a1d3ba052e56ae14 |
| Source note | uspto-grants-2007_01 |