Nicotinic Acid → HCID 10114635, compound

Participants

Reaction Steps

To 9.7 mg of 1-[1-[2-(piperidin-4-yl)-1-methylethyl]-piperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one which was synthesized by the method of Production Example 6, 1 ml of chloroform, 4.4 mg of nicotinic acid, 8 mg of 1-ethyl-3-[3-(dimethylamino)propyl]-carbodiimide hydrochloride, 6.4 mg of 1-hydroxybenzotriazole and 0.01 ml of triethylamine were added and stirred for an overnight. To the reaction liquid 1N aqueous sodium hydroxide solution and chloroform were added to separate the reaction liquid. The organic layer was dried over anhydrous sodium sulfate, the solvent was distilled off, and the residue was purified on silica gel chromatography (chloroform/methanol=11:1) to provide 10.1 mg of the title compound as a colorless solid.

Provenance & Evidence