4-Ethoxycarbonylphenylboronic acid → 4-[1-(2,5-Difluorobenzyl)-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-7-yl]benzoic acid ethyl ester

HRID 137418Notes

Reaction equation

HRID 137418 reaction equation
[CH2:21]([CH3:22])[O:23][C:24](=[O:25])[c:26]1[cH:27][cH:28][c:29]([B:32]([OH:33])[OH:34])[cH:30][cH:31]1.[F:1][c:2]1[c:3]([CH2:4][N:5]2[c:6]3[c:7]([n:11][cH:12][c:13]([I:15])[cH:14]3)[NH:8][CH2:9][CH2:10]2)[cH:16][c:17]([F:20])[cH:18][cH:19]1>>[F:1][c:2]1[c:3]([CH2:4][N:5]2[c:6]3[c:7]([n:11][cH:12][c:13](-[c:29]4[cH:28][cH:27][c:26]([C:24]([O:23][CH2:21][CH3:22])=[O:25])[cH:31][cH:30]4)[cH:14]3)[NH:8][CH2:9][CH2:10]2)[cH:16][c:17]([F:20])[cH:18][cH:19]1

Participants

3

Reactant 2

HCID 27343504-Ethoxycarbonylphenylboronic acidHCID 578860131-(2,5-Difluorobenzyl)-7-iodo-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine

Product 1

HCID 248531274-[1-(2,5-Difluorobenzyl)-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-7-yl]benzoic acid ethyl ester

Sources & evidence

ORD record
ord-a65c8923335641db9790bbca800edee0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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