Acetonitrile → HCID 21075154, compound

Participants

Reaction Steps

Preparation H6, Step 3: To a soultion of 3-tert-butyl-5-((2-cyanoethyl)carbamoyl)benzoat (520 mg, 1.8 mmol) in MeCN (15 mL) at 0° C. was added NaN3 (117 mg, 1.8 mmol), and Tf20 (0.3 mL, 1.8 mm0l). The mixture was stirred at rt for 16 h before aq NaHCO3 and EtOAc were added. The organic layer was separated and re-washed twice before it was collected, dried over Na2SO4, and concentrated to methyl 3-tert-butyl-5-(2-(2-cyanoethyl)-2H-tetrazol-5-yl)benzoate as an oil (450 mg, 80% yield). MS found: (M+H)+=314.

Provenance & Evidence