HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isoamyl acetoacetate → Isoamyl-alpha-acetyl-3-methoxy-4-hydroxy-5-isopropyl-cinnamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isoamyl acetoacetate | HCID 61296 | — |
| Reactant | Piperidin-1-yl-acetic acid | HCID 201097 | — |
| Reactant | 3-Methoxy-4-hydroxy-5-isopropyl benzaldehyde | HCID 22607964 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | Isoamyl-alpha-acetyl-3-methoxy-4-hydroxy-5-isopropyl-cinnamate | HCID 67318693 | — |
Reaction Steps
Condensation of 3-methoxy-4-hydroxy-5-isopropyl benzaldehyde with isoamyl acetoacetate in the presence of piperidine-acetic acid and benzene as the reaction medium at reflux temperature under continuous azeotropic water removal yields the title product. The reaction takes about 4 hrs for completion. The yield obtained is typically 90–95%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07166273B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-29fecc479f2141cb9f2cb8259e8ac85a |
| Source note | uspto-grants-2007_01 |