Potassium Hydroxide → HCID 10874467, compound

HRID 1374548Notes

Reaction equation

HRID 1374548 reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[C:5]([O:10][CH:11]([CH3:13])[CH3:12])=[CH:4][C:3]=1[CH:14]([CH2:17][CH2:18][CH2:19][C:20]1[CH:25]=[CH:24][C:23]([O:26][CH:27]([CH3:29])[CH3:28])=[CH:22][CH:21]=1)[C:15]#[N:16].[OH-:30].[K+]>C(O)C.O>[Br:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[C:5]([O:10][CH:11]([CH3:12])[CH3:13])=[CH:4][C:3]=1[CH:14]([CH2:17][CH2:18][CH2:19][C:20]1[CH:21]=[CH:22][C:23]([O:26][CH:27]([CH3:29])[CH3:28])=[CH:24][CH:25]=1)[C:15]([NH2:16])=[O:30]

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 10863486HCID 10863486, compound

Product 1

HCID 10874467HCID 10874467, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

α-[2-Bromo-4-methoxy-5-(1-methylethoxy)phenyl]-4-(1-methylethoxy)benzene pentane nitrile (30.0 g, 65.2 mmol) in ethanol (600 ml) is mixed with potassium hydroxide (60.0 g, 1.07 mol) in water (100 ml) and stirred for 6 hours at boiling temperature.

Sources & evidence

ORD record
ord-30f338b39b37402eadeb324e1d7b722f
Source dataset
uspto-grants-2007_01
Patent number
US07166588B2

Reaction notes

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