(2,3,5-trifluorophenyl)methanamine → HCID 58783220, compound

HRID 1374560Notes

Reaction equation

HRID 1374560 reaction equation
[N+](C1C=CC([O:10][C:11](=O)[O:12][C@H:13]([C:15](=[O:33])[NH:16][C@@H:17]2[C:23](=[O:24])[N:22]([CH3:25])[C:21]3[CH:26]=[CH:27][CH:28]=[CH:29][C:20]=3[N:19]([C:30](=[O:32])[CH3:31])[CH2:18]2)[CH3:14])=CC=1)([O-])=O.[F:35][C:36]1[C:43]([F:44])=[CH:42][C:41]([F:45])=[CH:40][C:37]=1[CH2:38][NH2:39]>O1CCOCC1>[C:30]([N:19]1[CH2:18][C@H:17]([NH:16][C:15]([C@@H:13]([O:12][C:11](=[O:10])[NH:39][CH2:38][C:37]2[CH:40]=[C:41]([F:45])[CH:42]=[C:43]([F:44])[C:36]=2[F:35])[CH3:14])=[O:33])[C:23](=[O:24])[N:22]([CH3:25])[C:21]2[CH:26]=[CH:27][CH:28]=[CH:29][C:20]1=2)(=[O:32])[CH3:31]

Participants

4

Reactant 2

HCID 3325139(2,3,5-trifluorophenyl)methanamineHCID 86597452HCID 86597452, compound

Product 1

HCID 58783220HCID 58783220, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

In an analogous manner to that described in Example 57 d), the aminolysis of the carbonic acid (S)-1-((S)-5-acetyl-1-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-ylcarbamoyl)-ethyl ester 4-nitro-phenyl ester by 2,3,5-trifluoro-benzylamine in dioxane yielded the title compound as a light yellow solid; MS: m/e=510 (M+NH4)+.

Workup

  1. customdescribed in Example 57 d

Sources & evidence

ORD record
ord-b0ec45e20e1d45bc8c24b1c8137d12c3
Source dataset
uspto-grants-2007_01
Patent number
US07166587B2

Reaction notes

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