HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → [(S)-2-Oxo-1-(2,2,2-trifluoro-ethyl)-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | 2,2,2-Trifluoroethyl trifluoromethanesulfonate | HCID 80366 | — |
| Reactant | tert-butyl N-[(3S)-2-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl]carbamate | HCID 22881971 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | [(S)-2-Oxo-1-(2,2,2-trifluoro-ethyl)-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-carbamic acid tert-butyl ester | HCID 69039568 | — |
Reaction Steps
In an analogous manner to that described in Example 53 a), the alkylation of the (S)-(2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-carbamic acid tert-butyl ester with 2,2,2-trifluoroethyl triflate, yielded, after chromatography on silica gel using a 99:1-mixture of dichloromethane and methanol as the eluent, the title compound as a white foam; MS: m/e=360 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07166587B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-fd4f9c88c5d248cf9795ffefd2d06477 |
| Source note | uspto-grants-2007_01 |