N,N-Dimethylglycine → HCID 18521584, compound

Participants

Reaction Steps

4.6 g of N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride are added, at 20° C., under an argon atmosphere, to a solution of 2.3 g of N,N-dimethylglycine, 3.2 cm3 of ethyl 4-piperidinecarboxylate, 3.4 cm3 of triethylamine and 0.27 g of hydroxybenzotriazol hydrate in 100 cm3 of dichloromethane. After stirring for 18 hours, the reaction mixture is washed with twice 100 cm3 of distilled water. The organic phase is dried over magnesium sulfate, filtered and then concentrated to dryness under reduced pressure (2.7 kPa). 4.6 g of ethyl 1-(dimethylaminoacetyl)piperidine-4-carboxylate are obtained in the form of a yellow oil.

Provenance & Evidence