HCID 21908315, compound → HCID 10208636, compound

HRID 1374636Notes

Reaction equation

HRID 1374636 reaction equation
[Br:1][C:2]1[C:7]([O:8]C)=[CH:6][CH:5]=[CH:4][C:3]=1[C:10]([CH3:34])([CH3:33])[CH2:11][C:12]([OH:32])([C:28]([F:31])([F:30])[F:29])[C:13]([NH:15][C:16]1[CH:17]=[CH:18][C:19]2[C:24](=[O:25])[O:23][N:22]=[C:21]([CH3:26])[C:20]=2[CH:27]=1)=[O:14]>C(Cl)(Cl)Cl>[Br:1][C:2]1[C:7]([OH:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:10]([CH3:34])([CH3:33])[CH2:11][C:12]([OH:32])([C:28]([F:29])([F:30])[F:31])[C:13]([NH:15][C:16]1[CH:17]=[CH:18][C:19]2[C:24](=[O:25])[O:23][N:22]=[C:21]([CH3:26])[C:20]=2[CH:27]=1)=[O:14]

Participants

3

Reactant 1

HCID 21908315HCID 21908315, compound

Product 1

HCID 10208636HCID 10208636, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Example 25 is produced analogously to Example 24 starting from the corresponding (−)-6-[4-(2-bromo-3-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethyl-valeroylamino]-4-methyl-2,3-benzoxazin-1-one. Flash point 227–231° C., [α]D=−94.3° (c 0.5 in chloroform).

Sources & evidence

ORD record
ord-92f68f641a534848a0200a5181e2cac6
Source dataset
uspto-grants-2007_01
Patent number
US07166592B2

Reaction notes

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