3,4-Dichloroaniline → 2-(3,4-Dichlorophenylamino)-4-methylamino-5-nitro-pyrimidine

Participants

Reaction Steps

6.47 g of 2-chloro-4-methylamino-5-nitro-pyrimidine and 11.7 g of 3,4-dichloro-aniline are heated to 160° C. in 60 ml of sulpholane within 45 minutes in an oil bath. After 40 minutes stirring at this temperature the reaction mixture is cooled and added to 600 ml of ice water. The precipitate is suction filtered, washed repeatedly with water and dried. The residue is stirred for one hour with 100 ml of ethyl acetate, the precipitate is suction filtered, washed with ethyl acetate and dried.

Provenance & Evidence