Formic Acid → HCID 21077551, compound

HRID 1374655Notes

Reaction equation

HRID 1374655 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[N:14]=[C:13]([NH:15][CH3:16])[C:12]([NH2:17])=[CH:11][N:10]=2)=[CH:4][CH:3]=1.[CH:18](O)=[O:19]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9]2[N:14]=[C:13]([NH:15][CH3:16])[C:12]([NH:17][CH:18]=[O:19])=[CH:11][N:10]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 284Formic AcidHCID 21077550HCID 21077550, compound

Product 1

HCID 21077551HCID 21077551, compound

Procedure

200 mg of 2-(4-chlorophenylamino)-4-methylamino-5-amino-pyrimidine are refluxed in 5 ml of formic acid for 5 hours. The reaction mixture is evaporated to dryness and then the residue is stirred with 15 ml of water. The solid is suction filtered, washed with water, briefly boiled with 15 ml ethanol, cooled, suction filtered again, then washed with hot ethanol and dried.

Workup

  1. customThe reaction mixture is evaporated to dryness
  2. filtrationfiltered
  3. washwashed with water
  4. temperaturecooled
  5. filtrationsuction filtered again
  6. washwashed with hot ethanol
  7. customdried

Sources & evidence

ORD record
ord-263b97990fed43febb476f830fc7ee03
Source dataset
uspto-grants-2007_01
Patent number
US07166599B2

Reaction notes

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