Dimethylformamide → HCID 53728725, compound

Participants

Reaction Steps

Bis((2R)-carboxy-2-t-butoxycarbonylaminoethyl)disulfide (5 g), 4-methoxybenzylamine (3.7 ml) and 1-hydroxybenzotriazole (3.84 g) were dissolved in a mixture of methylene chloride (50 ml) and DMF (10 ml). The solution was cooled with ice and EDC-HCl (5.45 g) was added thereto. The mixture was stirred for 12 hours. The reaction mixture was diluted with chloroform, washed with 1N hydrochloric acid, saturated aqueous sodium hydrogencarbonate and saturated aqueous sodium chloride, successively, dried over anhydrous magnesium sulfate. The organic layer was concentrated and the residue was washed with diehylether to give the title compound (8.15 g) having the following physical data.

Provenance & Evidence