Boron tribromide → HCID 178516348, compound

Participants

Reaction Steps

A solution of 2-(4-fluorophenyl)-3-(4-pyridyl)-5-methoxypyrazolo[1,5-a]pyridine (Example 5. 0.05 g, 0.16 mmol) in dry CH2Cl2 was cooled to about −78° C. under nitrogen. Boron tribromide (0.8 mL of a 1M solution in CH2Cl2, 0.8 mmol) was added dropwise and the mixture was stirred and warmed to room temperature over about 24 h. Ice was added to the reaction mixture and the resulting slurry was stirred for about 15 min. The CH2Cl2 was evaporated under vacuum and the resulting aqueous slurry was treated with conc hydrochloric acid (1 mL) and stirred. The aqueous solution was basified by the addition of a saturated solution of NaHCO3, and the resulting solid was collected by filtration and was dried under vacuum to give the title compound.

Provenance & Evidence